Research Database
Research
Studies on training and supplements (peer-reviewed papers, meta-analyses) with conclusions, study type and confidence.
Research
Research
- Meta-analysisConfidence: High2012
Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies
Te Morenga LA, Mallard S, Mann J / BMJ
Key point: 等カロリー条件(糖類のみを変更してカロリーを揃えた)では、砂糖の多寡で体重への有意差はなかった
- Randomized controlled trialConfidence: Moderate2014
Alcohol Ingestion Impairs Maximal Post-Exercise Rates of Myofibrillar Protein Synthesis following a Single Bout of Concurrent Training
Parr EB, Camera DM, Areta JL, Burke LM, Phillips SM, Hawley JA, Coffey VG / PLOS ONE
Key point: トレーニング後のアルコール摂取(1.5g/kg体重相当)は筋線維タンパク質合成を最大24%抑制した
- ReviewConfidence: Moderate2008
Assessment methods in human body composition
Lee SY, Gallagher D / Current Opinion in Clinical Nutrition and Metabolic Care
Key point: DEXA(二重エネルギーX線吸収法)は精度・再現性が高く体組成評価のゴールドスタンダードの一つ
- Randomized controlled trialConfidence: Moderate2017
Low-load bench press and push-up induce similar muscle hypertrophy and strength gain
Kikuchi N, Nakazato K / Journal of Exercise Science and Fitness
Key point: 負荷量を適切に設定したプッシュアップは低強度ベンチプレスと同等の上腕三頭筋・大胸筋の筋肥大を示した
- Randomized controlled trialConfidence: Moderate2014
The effectiveness of breakfast recommendations on weight loss: a randomized controlled trial
Dhurandhar EJ, Dawson J, Alcorn A, Larsen LH, Thomas EA, Cardel M, Bourland AC, Astrup A, St-Onge MP, Hill JO, Apovian CM, Shikany JM, Allison DB / American Journal of Clinical Nutrition
Key point: 朝食摂取推奨・非推奨・通常の3群間で16週後の体重変化に有意差はなかった
- Randomized controlled trialConfidence: Moderate2011
Effect of two different weight-loss rates on body composition and strength and power-related performance in elite athletes
Garthe I, Raastad T, Refsnes PE, Koivisto A, Sundgot-Borgen J / International Journal of Sport Nutrition and Exercise Metabolism
Key point: 急速減量グループは緩徐グループより体脂肪は多く落ちたが、除脂肪量(筋肉量)の損失も有意に大きかった
- Randomized controlled trialConfidence: Moderate2008
Effect of concurrent endurance and circuit resistance training sequence on muscular strength and power development
Chtara M, Chaouachi A, Levin GT, Chaouachi M, Chamari K, Amri M, Laursen PB / Journal of Strength and Conditioning Research
Key point: 有酸素運動→筋力トレーニングの順序では、筋力・パワー発達が逆の順序と比較して有意に低かった
- ReviewConfidence: Moderate2005
Hormonal responses and adaptations to resistance exercise and training
Kraemer WJ, Ratamess NA / Sports Medicine
Key point: コルチゾールは糖新生・タンパク質異化を促進し、慢性的な高値状態は筋タンパク合成を有意に抑制する
- Randomized controlled trialConfidence: Moderate2017
Crescent pyramid and drop-set systems do not promote greater strength gains, muscle hypertrophy, and changes on muscle architecture compared with traditional resistance training in well-trained men
Angleri V, Ugrinowitsch C, Libardi CA / European Journal of Applied Physiology
Key point: ボリューム等量条件下でドロップセットと通常セットの筋肥大に有意差なし
- Randomized controlled trialConfidence: Moderate2015
Food Order Has a Significant Impact on Postprandial Glucose and Insulin Levels
Shukla AP, Iliescu RG, Thomas CE, Aronne LJ / Diabetes Care
Key point: 野菜・タンパク質・脂質先食い群は炭水化物先食い群と比較して食後30分・60分の血糖値が有意に低かった
- Randomized controlled trialConfidence: Moderate2012
The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers
Bannai M, Kawai N, Ono K, Nakahara K, Mori N / Frontiers in Neurology
Key point: 就寝前グリシン3g摂取は翌日の主観的眠気を有意に軽減した(プラセボ比)
- Meta-analysisConfidence: Moderate2018
Effects of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in trained and competitive athletes: A meta-analysis of randomized controlled trials
Sanchez-Martinez J, Santos-Lozano A, Garcia-Hermoso A, Sadarangani KP, Cristi-Montero C / Journal of Science and Medicine in Sport
Key point: HMBのトレーニング経験者・競技者への筋肉量増加効果は統計的に有意でないケースが多かった
- ReviewConfidence: Moderate2015
Effects of intermittent fasting on body composition and clinical health markers in humans
Tinsley GM, La Bounty PM / Nutrition Reviews
Key point: 16〜24時間の断食では、タンパク質摂取量が確保されていれば顕著な筋タンパク質分解は起きにくい
- Randomized controlled trialConfidence: Moderate2018
Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial
Vargas S, Romance R, Petro JL, Bonilla DA, Galancho I, Espinar S, Kreider RB, Benitez-Porres J / Journal of the International Society of Sports Nutrition
Key point: ケトジェニックグループは通常食グループより体脂肪減少が有意に大きかった(-2.2kg vs -1.5kg)
- Meta-analysisConfidence: High2015
Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis
Tobias DK, Chen M, Manson JE, Ludwig DS, Willett W, Hu FB / Lancet Diabetes and Endocrinology
Key point: 12ヶ月以上の長期介入では低脂肪食と低糖質食の体重減少に有意差なし
- ReviewConfidence: Moderate2004
Vitamin and mineral status: effects on physical performance
Lukaski HC / Nutrition
Key point: 鉄・ビタミンD・マグネシウムなどの欠乏は有酸素パフォーマンスと筋力に明確な悪影響を与える
- Meta-analysisConfidence: High2010
Resistance exercise for muscular strength in older adults: A meta-analysis
Peterson MD, Rhea MR, Sen A, Gordon PM / Ageing Research Reviews
Key point: 50歳以上の成人でも抵抗性運動により筋力が平均25%以上向上した
- Randomized controlled trialConfidence: Moderate2011
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B / Clinical Science
Key point: 8週間のオメガ3補充(EPA+DHA 4g/日)はインスリン・アミノ酸刺激に対するMPS応答を有意に増強した
- ReviewConfidence: Moderate2015
A review of resistance training-induced changes in skeletal muscle protein synthesis and their contribution to hypertrophy
Damas F, Phillips SM, Vechin FC, Ugrinowitsch C / Sports Medicine
Key point: トレーニング開始後1〜4週間の筋力向上の多くは神経系の適応(運動単位の動員効率向上)によるもの
- Randomized controlled trialConfidence: Moderate2016
Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men
Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, Schnak JA, Bond KF, Carter JM, Aragon AA / Journal of Strength and Conditioning Research
Key point: 3分休憩グループは1分休憩グループと比較して筋肉量の増加が有意に大きかった(上腕二頭筋・大腿四頭筋)
- ReviewConfidence: Moderate2011
Sleep and muscle recovery: endocrinological and molecular basis for a new and promising hypothesis
Dattilo M, Antunes HK, Medeiros A, Monico-Neto M, Souza HS, Lee KS, Tufik S, de Mello MT / Medical Hypotheses
Key point: 睡眠中(特に深睡眠)は成長ホルモン分泌のピークであり、睡眠不足はGH分泌を顕著に抑制する
- Meta-analysisConfidence: Moderate2010
Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis
Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ / Fertility and Sterility
Key point: 15件の研究(男性384名)のメタ分析で、大豆タンパク質・イソフラボンはテストステロン濃度に有意な影響を与えなかった
- Randomized controlled trialConfidence: Moderate2010
Effect of agonist-antagonist complex resistance training on upper body strength and power development
Robbins DW, Young WB, Behm DG, Payne WR / Journal of Sports Sciences
Key point: 拮抗筋スーパーセットは通常のストレートセットと比較して筋力・パワー向上に有意差なし
- Randomized controlled trialConfidence: Moderate2010
Water Consumption Increases Weight Loss During a Hypocaloric Diet Intervention in Middle-aged and Older Adults
Dennis EA, Dengo AL, Comber DL, Flack KD, Savla J, Davy KP, Davy BM / Obesity
Key point: 食前500mL水摂取グループは12週間で非摂取グループより平均2.3kg多く体重が減少した
- Randomized controlled trialConfidence: Moderate2009
Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM / Journal of Applied Physiology
Key point: ホエイはカゼイン・ソイと比較してレジスタンス運動後の筋タンパク質合成を有意に高めた
- ReviewConfidence: Moderate2020
Physiological differences between females and males in resistance training outcomes: a systematic review
Roberts BM, Nuckols G, Krieger JW / Journal of Strength and Conditioning Research
Key point: 女性のテストステロン濃度は男性の約5〜10%であり、同強度のトレーニングでの筋肉量増加の絶対量は男性より少ない
- ReviewConfidence: Moderate2016
B vitamins and energy metabolism: roles, deficiencies, and supplementation effects — a review
Kennedy DO / Nutrients
Key point: B vitamins are essential cofactors in ATP production, the TCA cycle, and fatty acid β-oxidation
- Meta-analysisConfidence: High2013
Dietary Nitrate (Beetroot) Supplementation and Aerobic Exercise Performance: A Systematic Review and Meta-analysis
Hoon MW, et al. / International Journal of Sport Nutrition and Exercise Metabolism
Key point: Beetroot-derived nitrate supplementation significantly improved time-trial performance (effect size d=0.79)
- Meta-analysisConfidence: High2002
Calcium supplementation and bone mineral density in postmenopausal women: a meta-analysis
Shea B,Wells G,Cranney A,Zytaruk N,Robinson V,Griffith L,Hamel C,Ortiz Z,Peterson J,Adachi J,Tugwell P,Guyatt G / Endocrine Reviews
Key point: Calcium supplementation significantly reduced BMD loss at the spine and femur in postmenopausal women
- Randomized controlled trialConfidence: Moderate2017
Effects of collagen peptide supplementation on joint pain, skin elasticity, and cartilage protection: a randomized controlled trial
Shaw G,Lee-Barthel A,Ross ML,Wang B,Baar K / American Journal of Clinical Nutrition
Key point: Significant improvement in collagen content and mechanical properties in tendon tissue engineering model
- Meta-analysisConfidence: Moderate2022
Effects of CoQ10 Supplementation on Cardiovascular Function and Energy Metabolism: A Meta-Analysis
Mantle D, Hargreaves IP, et al. / Nutrients (MDPI)
Key point: CoQ10 100–300 mg/day reduced statin-induced myalgia (consistent across multiple RCTs)
- Meta-analysisConfidence: Moderate2015
Meta-analysis of curcumin supplementation on exercise-induced inflammation and delayed onset muscle soreness (DOMS)
Yavari A,Javadi M,Mirmiran P,Bahadoran Z / Asian Journal of Sports Medicine
Key point: Significantly reduced post-exercise inflammatory markers (CRP, IL-6, TNF-α)
- ReviewConfidence: Moderate2011
Effects of electrolyte and hydration strategies on exercise performance and muscle cramp prevention: a review
Shirreffs SM,Sawka MN / Journal of Sports Sciences
Key point: Dehydration exceeding 2% body weight significantly impairs performance
- Meta-analysisConfidence: High2015
Folic acid supplementation for prevention of neural tube defects: a meta-analysis of randomized trials
De-Regil LM,Peña-Rosas JP,Fernández-Gaxiola AC,Rayco-Solon P / Cochrane Database of Systematic Reviews
Key point: Folic acid supplementation reduced NTD risk by approximately 72% (relative risk 0.28)
- Meta-analysisConfidence: Moderate2010
Glucosamine and Chondroitin for Joint Pain and Cartilage Protection: Meta-Analysis Including the GAIT Trial
Wandel S, et al. / BMJ
Key point: No significant difference from placebo overall (moderate OA)
- Meta-analysisConfidence: High2014
Iron Deficiency and Aerobic Exercise Performance: A Systematic Review and Meta-analysis
Pasricha SR, et al. / British Journal of Haematology
Key point: Iron supplementation improved VO2max by an average of +3.9 ml/kg/min (95% CI: 1.9–5.9)
- Meta-analysisConfidence: Moderate2016
Effects of L-Carnitine Supplementation on Fat Metabolism, Exercise Performance, and Body Composition: A Meta-Analysis
Pooyandjoo M, et al. / Obesity Reviews
Key point: Significant but small reduction in body weight vs placebo
- ReviewConfidence: Low2010
Effects of Maca Supplementation on Libido, Energy, and Exercise Performance: A Systematic Review
Shin BC, et al. / BMC Complementary and Alternative Medicine
Key point: Weak to moderate evidence for improvement in sexual desire (multiple RCTs)
- Meta-analysisConfidence: High2013
Meta-analysis of melatonin supplementation effects on sleep quality and sleep onset
Ferracioli-Oda E,Qawasmi A,Bloch MH / PLOS ONE
Key point: Reduced sleep onset latency by an average of 7.06 minutes vs placebo
- Meta-analysisConfidence: Moderate2014
Effects of probiotics on gut microbiota, IBS symptoms, and immune function: a meta-analysis
Ford AC,Quigley EM,Lacy BE,Lembo AJ,Saito YA,Schiller LR,Soffer EE,Spiegel BM,Moayyedi P / American Journal of Gastroenterology
Key point: Significantly improved global IBS symptom scores vs placebo (RR 0.79)
- Meta-analysisConfidence: Moderate2018
Effects of Taurine Supplementation on Exercise Performance and Muscle Fatigue: A Meta-Analysis
Waldron M, et al. / Sports Medicine
Key point: Significant improvement in endurance (time to exhaustion) with moderate effect size
- ReviewConfidence: Moderate2017
Bioavailability and Anti-Inflammatory Effects of Turmeric and Curcumin: A Systematic Review
Hewlings SJ, Kalman DS / Foods
Key point: Curcumin content in turmeric powder is only 2–5%
- Meta-analysisConfidence: Moderate1993
Meta-analysis of vitamin C supplementation on immune function and upper respiratory tract infection risk after exercise
Peters EM,Goetzsche JM,Grobbelaar B,Noakes TD / American Journal of Clinical Nutrition
Key point: Reduced upper respiratory infection risk by ~50% after intense exercise vs placebo
- Randomized controlled trialConfidence: Moderate2013
Effects of vitamin K2 (MK-7) supplementation on bone mineral density, bone turnover markers, and arterial calcification: a randomized controlled trial
Knapen MH,Drummen NE,Smit E,Vermeer C,Theuwissen E / Osteoporosis International
Key point: Significant attenuation of lumbar spine and femoral neck BMD decline
- Randomized controlled trialConfidence: Moderate1996
Effects of Zinc Supplementation on Testosterone Levels and Immune Function
Prasad AS, et al. / Nutrition
Key point: In zinc-deficient older men, testosterone approximately doubled with supplementation (recovery within normal range)
- Randomized controlled trialConfidence: Moderate2015
Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
Wankhede S,Langade D,Joshi K,Sinha SR,Bhattacharyya S / Journal of the International Society of Sports Nutrition
Key point: Bench press and leg extension strength significantly improved vs placebo
- Meta-analysisConfidence: Moderate2012
Effects of β-alanine supplementation on exercise performance: a meta-analysis
Hobson RM, Saunders B, Ball G, Harris RC, Sale C / Amino Acids
Key point: β-alanine supplementation significantly improved high-intensity exercise performance vs. placebo (SMD = 0.374)
- Randomized controlled trialConfidence: Moderate2010
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
Pérez-Guisado J,Jakeman PM / Journal of Strength and Conditioning Research
Key point: Citrulline malate increased bench press repetitions by an average of 52.92%
- ReviewConfidence: Moderate2018
Glutamine supplementation in sport and exercise: A review in the field of immunology and cell biology
Cruzat V,Macedo Rogero M,Noel Keane K,Curi R,Newsholme P / Nutrients
Key point: Plasma glutamine decreases after intense exercise, associated with transient immune suppression
- Randomized controlled trialConfidence: Moderate2012
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
Abbasi B,Kimiagar M,Sadeghniiat K,Shirazi MM,Hedayati M,Rashidkhani B / Journal of Research in Medical Sciences
Key point: Subjective sleep time and sleep efficiency improved significantly
- Randomized controlled trialConfidence: Moderate2015
Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men
Schoenfeld BJ, Peterson MD, Ogborn D, Contreras B, Sonmez GT / Journal of Strength and Conditioning Research
Key point: No significant difference in muscle thickness or lean mass between high-load (3–5RM) and low-load (25–35RM) at 8 weeks
- Meta-analysisConfidence: Moderate2017
Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-Analysis
Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW / Journal of Strength and Conditioning Research
Key point: No significant difference in hypertrophy between low-load (≤60% 1RM) and high-load (≥65% 1RM) when volume and effort are equated
- Meta-analysisConfidence: Moderate2015
Effects of vitamin D supplementation on muscle strength in athletes: A systematic review
Tomlinson PB,Joseph C,Angioi M / Journal of Science and Medicine in Sport
Key point: Vitamin D supplementation may improve muscle strength in deficient athletes
- Randomized controlled trialConfidence: Low2009
Effect of zinc and magnesium supplementation on testosterone and insulin-like growth factor-1 in resistance-trained men
Koehler K,Parr MK,Geyer H,Mester J,Schänzer W / European Journal of Clinical Nutrition
Key point: Blood zinc and magnesium levels increased, but no significant difference in testosterone
- Meta-analysisConfidence: Moderate2019
Effect of branched-chain amino acid supplementation on muscle soreness following exercise: a meta-analysis
Fedewa MV, et al. / International Journal for Vitamin and Nutrition Research
Key point: BCAA supplementation significantly reduced DOMS scores at 24–72 h post-exercise vs. placebo
- ReviewConfidence: Moderate2017
Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?
Wolfe RR / Journal of the International Society of Sports Nutrition
Key point: BCAA alone can theoretically stimulate MPS by up to ~30%, but missing EAAs limit actual anabolic impact
- Meta-analysisConfidence: Moderate2018
Caffeine ingestion improves muscular strength and power (meta-analysis)
Grgic J, et al. / Journal of the International Society of Sports Nutrition
Key point: Small gains in maximal strength and power
- Meta-analysisConfidence: High2017
Creatine supplementation augments gains in strength and lean mass from resistance training (meta-analysis)
Chilibeck PD, et al. / Open Access Journal of Sports Medicine
Key point: Significantly greater lean-mass gains with creatine
- Meta-analysisConfidence: High2018
Protein supplementation augments resistance-training-induced gains in muscle mass and strength (meta-analysis)
Morton RW, et al. / British Journal of Sports Medicine
Key point: Protein adds to lean-mass and strength gains
- ObservationalConfidence: Low2011
Sleep extension improves athletic performance
Mah CD, et al. / Sleep
Key point: Sprint, shooting accuracy and reaction time improved
- Meta-analysisConfidence: Moderate2017
Dose-response relationship between weekly sets (training volume) and hypertrophy (systematic review)
Schoenfeld BJ, et al. / Journal of Sports Sciences
Key point: Dose-response between weekly sets and hypertrophy