Strength and Hypertrophy Adaptations Between Low- vs. High-Load Resistance Training: A Systematic Review and Meta-Analysis
Schoenfeld BJ, Grgic J, Ogborn D, Krieger JW
Evidence is still building up
Summary
When volume is equated and effort is matched, low-load high-rep and high-load low-rep training produce similar hypertrophy. High-load training produces superior strength gains.
Key findings
- 1
No significant difference in hypertrophy between low-load (≤60% 1RM) and high-load (≥65% 1RM) when volume and effort are equated
- 2
High-load training produced significantly greater maximal strength (1RM) gains
- 3
Effort near failure is a prerequisite for hypertrophy with low loads
- 4
Total volume load (weight × reps × sets) is the key driver; absolute load is secondary
Related research
Dose-response relationship between weekly sets (training volume) and hypertrophy (systematic review)
Journal of Sports Sciences, 2017
More weekly sets tended to produce greater hypertrophy (a dose-response relationship). Groups doing 10+ sets/week outgained those doing under 5, though volume exceeding recovery capacity can backfire.
Effects of Low- vs. High-Load Resistance Training on Muscle Strength and Hypertrophy in Well-Trained Men
Journal of Strength and Conditioning Research, 2015
18 resistance-trained men were randomized to high-load (3–5 rep) or low-load (25–35 rep) training for 8 weeks. Both groups produced similar hypertrophy; maximal strength gains were significantly greater in the high-load group.
Last checked: 2026-06-23